Ovarian cancer patients were
enrolled in a study completed by Lutgendorf et al. (2008) that examined
biobehavioral factors, such as depression and stress, effects on angiogenic
cytokines and matrix metalloproteinases. Covariates included in the study
included age, education, martial status, and stage of cancer. Results of the
study demonstrate that depressed patients show significant elevations of MMP-9
(mean= 69.89, SD=19.02) compared to those who were not depressed (p= <
0.0001). Results of the study suggest
that the tumor microenvironment of ovarian cancer patients is influenced by
stress- related biobehaviroal factors.
Lutgendorf, S. K., Lamkin, D. M., Jennings, N. B.,
Arevalo, J. M. G., Penedo, F., DeGeest, K., … Sood, A. K. (2008). Biobehavioral
influences on matrix metalloproteinase expression in ovarian carcinoma. Clinical
Cancer Research : An Official Journal of the American Association for Cancer
Research, 14(9), 6839–6846. doi:10.1158/1078-0432.CCR-08-0230
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