The mechanisms of epigenetics and
cancer are discussed in a review written by Dawson et al. (2012). Advances in
technology and the research completed by International Cancer Genome Consortium
has resulted in information on protein-coding genes for many cancers, otherwise
known as epigenetic information. Chromatin
modifications play a pivotal role in regulating DNA-template information,
transcription, repair, and replication. These
dynamic modifications determine accessibility to specific parts of DNA, and
provide information for epigenetic regulation. The epigenome displays a dynamic
ability to change, which allows for novel therapeutic approaches discussed in
this review.
Dawson, M. a,
Kouzarides, T., & Huntly, B. J. P. (2012). Targeting epigenetic readers in
cancer. The New England Journal of Medicine, 367(7), 647–57.
doi:10.1056/NEJMra1112635
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