Regulation of our internal environment involves three systems: the nervous system, immune system, and endocrine system. The hypothalamic-pituitary-adrenal (HPA) axis is integral to all three of these systems and is often disrupted and hyperactive in major depression (MD). Neuroendocrine stimulation research suggests that negative coping strategies predicts the plasma cortisol response, which is controlled by the HPA-axis. Results of the study by N.Hohne et al.(2014) indicate that subjects with a lifetime history of major depression have HPA-axis dysregulation and negative coping strategies, compared to individuals that have never been depressed.
N. Hohne et al.(2014). Increased HPA axis response to pyschosocial stress in remitted depression: the influence of coping style, Biological Psychology, 103 (September 2014), 265-267. http://dx.doi.org/10.1016/j.biopsycho.2014.09.008
N. Hohne et al.(2014). Increased HPA axis response to pyschosocial stress in remitted depression: the influence of coping style, Biological Psychology, 103 (September 2014), 265-267. http://dx.doi.org/10.1016/j.biopsycho.2014.09.008
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