The botanical known as Ashwagandha (Withania somnifera) is often used for its adaptogenic properties, which modulate general conditions like insomnia, stress, anxiety, and cognitive function. GABA is the inhibitory neurotransmitter in the central nervous system mediating pathological processes such as anxiety, depression, epilepsy, and other cognitive disorders. The study completed by Candelario et al.(2015) aimed to examine the root extract of Ashwagandha and its constituents, and how they inhibit GABA receptors in the CNS. Results of the study suggest that the key constituents in Ashwagandha may beneficially influence the signaling dysfunction found in general anxiety disorders, sleep disorders, and cognitive disorders by targeting GABA in the CNS.
Candelario M. et al.(2015) Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAa and GABAp receptors. Journal of Ethnopharmacology, 171 (May 2015), 264-272. http://dx.doi.org/10.1016/j.jep.2015.05.058
Candelario M. et al.(2015) Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAa and GABAp receptors. Journal of Ethnopharmacology, 171 (May 2015), 264-272. http://dx.doi.org/10.1016/j.jep.2015.05.058
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